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Riboflavin contributes to the reduction of tiredness and fatigue

Elevated SAH, Glutathione and Undermethylation Toxic overload and depression may be connected when environmental exposures, gut-derived toxins, oxidative stress, glutathione depletion and impaired clearance reduce neurological resilience

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FIGURE 4 Research on PD patients has shown abnormal expression of proteins involved in autophagy (Table 5) and Atg and ULK genes, which increased upstream regulators of autophagy and decreased downstream regulators, strengthening the link between the disease and this cellular mechanism (Miki et al., 2018)